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Job details

Principal Software Engineer

RefinedScience is a data-driven biotech partner focused on integrating clinical and biological data to accelerate discovery and improve patient outcomes. We are looking for a Principal Software Engineer to build scalable cloud-based tools and developer workflows, set engineering standards as the first hire on the end-user software team, and collaborate with data science, clinical, and informatics teams to accelerate research.

Skills

  • Proficiency in one or more languages (e.g., C#, React/Native, PHP)
  • Strong cloud architecture and deployment experience
  • Scripting with Bash, Python, PowerShell
  • Containerization using Docker and Kubernetes
  • Software security best practices
  • Experience with asynchronous, event-driven architectures
  • Excellent written and verbal communication
  • Strong analytical and problem-solving skills
  • Ability to work independently and collaboratively

Responsibilities

  • Design, implement, and maintain cloud-based software tools for data visualization and analysis
  • Translate prototypes from data scientists and bioinformaticians into robust end-user software
  • Lead development of software capabilities and establish engineering standards and best practices
  • Advocate for and guide implementation of modular, reusable, and maintainable code
  • Leverage generative AI to accelerate development and improve developer productivity
  • Evaluate and adopt new technologies to improve software products and development processes
  • Manage cloud services including monitoring, backup, disaster recovery, security, and compliance
  • Promote and train teams on containerization technologies (Docker, Kubernetes) and deployment best practices
  • Support deployment and maintenance of internal front-end applications and related cloud networking (load balancers, DNS, SSL, routers, NAT)
  • Create and maintain technical documentation and runbooks for cloud solutions and processes
  • Implement monitoring and alerting to proactively detect and resolve issues

Education

  • Bachelor’s degree in Computer Science, Engineering, or related field (or equivalent experience)
  • Master’s degree or advanced technical training preferred

Benefits

  • Medical, dental, and vision insurance
  • Life, AD&D, short-term and long-term disability insurance
  • HSA spending accounts
  • 22 vacation days
  • 10 paid holidays and 120 hours sick time per year
  • 401(k) plan
  • Remote-first flexibility and professional development support
To read the complete job description, please click on the ‘Apply’ button

Average salary estimate

$180000 / YEARLY (est.)
min
max
$160000K
$200000K

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At RefinedScience, we seamlessly integrate top-tier clinical and biological data with expert knowledge to provide unparalleled insights. We maximize patient impact with these unique insights by optimizing clinical trial probability of success and...

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SENIORITY LEVEL REQUIREMENT
TEAM SIZE
SALARY RANGE
$160,000/yr - $200,000/yr
EMPLOYMENT TYPE
Full-time, remote
DATE POSTED
October 4, 2025
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