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Principal Scientist, Machine Learning, Origination

Pioneering Intelligence (part of Flagship Pioneering) builds AI-first ventures across health and sustainability. They are seeking a Principal Scientist (Embedded ML/Computational) to lead multiple AI/ML and computational projects across early-stage ventures, own methods and platform development, and guide model benchmarking, scaling, and production delivery while partnering closely with venture teams.

Skills

  • Advanced proficiency in Python and modern ML frameworks (PyTorch, JAX, TensorFlow).
  • Experience in model development, benchmarking, scaling, and production deployment.
  • Familiarity with version control, databases, and informatics software.
  • Experience driving cross-functional teams in fast-paced, entrepreneurial settings.
  • Record of high-impact scientific output (publications, patents, or internal reports).

Responsibilities

  • Lead development, implementation, reporting, and control of multiple AI/ML or computational projects across assigned ventures.
  • Own technical direction: method development, pipeline design, benchmarking, scaling, and production-grade implementation including LLM/agentic workflows.
  • Promote best practices and operational excellence across cross-functional collaborators.
  • Manage or coordinate scientists and engineers, mentor early hires, and support recruiting and interviews.
  • Contribute to project planning, budgeting, resourcing, risk identification, and tradeoff analysis.
  • Scout and synthesize emerging literature and AI/ML landscape to propose new strategies and opportunities.
  • Represent Pioneering Intelligence to portfolio companies and external partners; present at conferences and meetings.
  • Translate complex technical findings for diverse audiences and influence project direction.

Education

  • Master’s or PhD in machine learning, mathematics, statistics, computational sciences, bioinformatics, computational biology, or related field.

Benefits

  • Healthcare coverage
  • Annual incentive program
  • Retirement benefits
  • Broad range of additional company benefits
To read the complete job description, please click on the ‘Apply’ button

Average salary estimate

$247000 / YEARLY (est.)
min
max
$208000K
$286000K

If an employer mentions a salary or salary range on their job, we display it as an "Employer Estimate". If a job has no salary data, Rise displays an estimate if available.

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Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied... a unique, hypothesis-driven innovation proces...

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FUNDING
DEPARTMENTS
SENIORITY LEVEL REQUIREMENT
TEAM SIZE
SALARY RANGE
$208,000/yr - $286,000/yr
EMPLOYMENT TYPE
Full-time, onsite
DATE POSTED
November 3, 2025
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