Scientist, Assay Automation

Use Your Power for Purpose

At Pfizer, our purpose is to deliver breakthroughs that change patients’ lives. Your work will have a profound impact on improving patients' lives globally. Whether you are involved in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, you will leverage cutting-edge design and process development capabilities to accelerate and deliver best-in-class medicines to patients worldwide.

What You Will Achieve
 

We are seeking a Data Scientist with strong skills in programming, database architecture and tool development for the analysis of high throughput screening (HTS) data to join our HTS team within the Discovery Biology and Pharmacology (DBP) group in Groton, CT. The HTS team is building internal capabilities to support automated high-throughput screening to identify novel lead matter in support of Pfizer’s small molecule portfolio.  The successful candidate will combine his/her/their expertise in coding and data analysis with strong collaboration and organizational skills to partner with colleagues across functions and to support multiple disease areas of focus.

Key Responsibilities:

The successful candidate will help to build Pfizer’s internal HTS capability in DBP by designing and executing automated data analysis and publishing workflows to enable HTS including primary, confirmation, counter screen, and selectivity assays in 384-well and 1536-well plate formats, all with minimal supervision. This scientist will build and maintain a tracking dashboard that can organize and report the status of HTS campaigns, the output of screening efforts in terms of milestone achievement, and meta data associated with each project.

Successful candidates will be expected to:

• Ensure start-to-finish data flow encompassing registered compounds in source plates, data output from plate readers, QC analysis, etc. on fully and semi-automated platforms.

• Independently design and execute protocols to upload, analyze, report and publish both internal and external data into corporate databases,

• Create workflows that can analyze and report plate level, layer-level, and well level calculations using data analysis software including Genedata screener.

• Test new versions of software and interact with software developers to ensure proper function in both development and production modes

• Program automation systems using Cellario, Biomek, Echo, and other software platforms for efficient execution of HTS campaigns

• Create and maintain a dashboard that captures the timelines of key milestones of HTS campaigns, allows for scheduling of multiple HTS projects on several different automation platforms and illustrates bottlenecks and areas for improvement.

• Construct a reporting tool that informs senior management of the status and timelines of each HTS campaign.

• Maintain a database of HTS results and meta data that can be queried to answer a variety of screening questions

• Actively participate in the scouting, evaluation, creation, and implementation of new data solutions to enhance workflow efficiencies and/or capabilities. 

Here Is What You Need (Minimum Requirements)

• BS or equivalent with 6+ years OR MS with 4+ years of experience relevant industry experience

• Demonstrated experience writing codes, uploading data, publishing data, and managing databases

• Knowledge of at least one language (python, Java, Excel VBA, C#, SQL) is required.

• Familiarity with application programming interfaces (APIs)

• Excellent customer service, time management, computer, verbal and written communication skills

Bonus Points If You Have (Preferred Requirements)

• BS in Biology, Biochemistry, Bioinformatics, Bioengineering or related life-sciences field

• Ability to thrive in a fast-paced environment, whether working independently or as part of a team

• Expertise in SQL and python

• Knowledge of Genedata screener

• Previous experience with project management software (Microsoft Project, Jira, Smartsheets or other)

• Thorough understanding of different API architectures like REST and SOAP

• Experience with Biomek I7, Echo acoustic liquid handlers, Tempest reagent dispensers, Pherastar plate readers and Envision plate readers

• Experience with HighRes or other automated systems

• Previous experience providing laboratory and automation support

• Familiarity with in vitro assay data (fluorescence, HTRF, TR-FRET, SPA, luminescence) commonly used in pharmacology screening

  

PHYSICAL/MENTAL REQUIREMENTS

• Lifting, sitting, standing, walking, bending

• Ability to perform mathematical calculations

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Majority of work will be performed during the standard workday, but ability to work flexible hours when needed is preferrable

Other Job Details:

• Last Date to Apply: August 07, 2025.

• Work Location Assignment: On Premise

• No relocation Support Available

The annual base salary for this position ranges from $77,100.00 to $128,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Research and Development

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