At Matterworks we are building AI tools to extract insights from the ever-growing corpora of biological data and to unlock opportunities in therapeutic discovery, development, and manufacturing. We are building large-scale deep learning models of biological data to predict the phenotype and behavior of biological systems.
Position Overview
As a Principal Machine Learning Scientist, you will be a technical leader for our research and development efforts. You will be responsible for setting the long-term technical vision and strategy for our deep learning architecture. This is a strategic, hands-on role for a scientist who is passionate about architecting foundational neural networks and can lead ambitious, multi-year research and engineering initiatives. You will be instrumental in guiding the company's scientific direction and mentoring our talented team of scientists.
Key Responsibilities
Architectural Vision and Strategy: Define and drive the long-term vision for our core deep learning architecture. Make critical decisions on the foundational design of our neural networks to ensure they are scalable, robust, and optimized for interpreting mass spectrometry data.
Foundational Model Development: Lead the conceptualization, design, and implementation of innovative deep learning models. Your work will involve creating novel network architectures and algorithms tailored to scientific discovery.
Scientific Leadership: Provide intellectual leadership to the machine learning team and the broader company. Stay at the forefront of academic and industry advancements in deep learning, particularly as they apply to chemistry and biology, and guide the team in applying cutting-edge techniques.
Cross-Functional Collaboration: Work closely with leadership in engineering, product, and scientific discovery to align machine learning initiatives with company-wide goals.
Mentorship and Guidance: Mentor and develop our team of machine learning scientists, fostering a culture of technical excellence, creativity, and rigorous scientific inquiry.
Qualifications
Ph.D. in a quantitative field such as Computer Science, Chemistry, Physics, or a related discipline, or equivalent research experience.
10+ years of experience in machine learning, with a significant focus on architecting novel deep learning systems.
Demonstrated experience in leading the architectural design of complex deep learning systems. This should be evident through publications, patents, or a portfolio of shipped products.
Expertise or strong familiarity with machine learning for spectral analysis, molecular structure prediction, or novel molecular representation learning is highly preferred.
A strong publication record in top-tier machine learning or scientific journals (e.g., NeurIPS, ICML, Nature, Science) is highly desirable.
Proficiency with common scientific data formats (e.g., HDF5, mzML, zarr).
Given the cross-disciplinary and innovative nature of our work, effective collaboration and communication are critical to our progress. We operate in a flexible hybrid model that accommodates both fully remote team members and those who work full-time from our Somerville, MA office. While some positions may require regular in-person presence for hands-on work or local collaboration, many roles can be performed remotely with team members distributed across various locations.
Matterworks offers a competitive base salary, stock options, and benefits (health & dental, vision, long- and short-term disability, life insurance, 401k with company match). Employees enjoy a flexible work & unlimited time away policy, commuter benefits and parking, regular team meals and outings, and company support for continued education/coursework and conference participation.
Matterworks, Inc. is an equal opportunity employer. All candidates for employment at Matterworks are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, sexual orientation, or any other category protected by law.
If an employer mentions a salary or salary range on their job, we display it as an "Employer Estimate". If a job has no salary data, Rise displays an estimate if available.
Impact drug discovery by applying and validating state-of-the-art ML and cheminformatics models to active small-molecule programs at Genesis Therapeutics.
Senior AI Engineer role at Constant Contact to develop and deploy production AI/ML solutions—especially leveraging foundation models, embeddings, and modern MLOps—to enhance product experiences and business outcomes.
Senior Data Scientist / ML Engineer needed to build and productionize personalization, search, and ranking models that drive member discovery and engagement for Sam's Club.
Faire is hiring a Senior Data Scientist / Machine Learning Engineer to lead ML and LLM-driven initiatives that improve listing quality and product discovery for retailers on its marketplace.
Build and productionize physics-aware LLMs and advanced ML systems at Apiphany to convert complex engineering data into actionable insights for top manufacturers.
Develop and deploy advanced AI and deep learning models for drug discovery while collaborating with cross-functional scientific teams at a remote US-based research-driven company.