Vice President Clinical Development

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history.

As Vice President Clinical Development, your initial focus will be as lead clinician for our pivotal Phase 3 program in Frontotemporal Dementia. Reporting to the Chief Medical Officer, you’ll own the post-readout clinical strategy and execution. You'll lead regulatory engagement with the US FDA and drive clinical leadership through a critical period leading toward potential filing and launch. You’ll work cross-functionally with Clinical Operations, Regulatory Affairs, Biometrics, and Commercial colleagues to help us achieve our mission of delivering transformative therapies to patients with neurodegenerative diseases.

We’re a team that works together to solve hard problems. We move fast, and we’re not afraid to change direction when the science demands it. You’ll thrive here if you are mission-driven, collaborative, deeply curious, and excited to shape the future of medicine.

• Serve as lead clinical expert for our Phase 3 FTD program following data readout, driving all clinical strategies and partnering on regulatory activities to enable filing!
• Lead strategic and operational engagement with the US FDA, including participation in key meetings and authorship of major regulatory submissions.
• Own the clinical development plan from late-stage study execution through potential BLA filing and NDA approval.
• Provide clinical insights that guide program decisions, ensuring scientific rigor, patient safety, and regulatory compliance at every step.
• Integrate innovative technologies—including AI—to accelerate timelines and improve decision-making across development stages!

• MD, MD/PhD with at least 10 years of clinical drug development experience.
• Proven track record leading programs in rare diseases and CNS, or alternatively, in neurodegenerative disease.
• Demonstrated success bringing therapies through late-stage development, US FDA interactions and filing, and drug launch. You have been the point-person leading filings with the FDA.
• Experience working independently and cross-functionally in fast-paced, matrixed environments. You are a team player and know how to influence your cross-functional colleagues.
• Active user of large language models (LLMs) with a strong interest in evolving AI applications in clinical development and commercialization-readiness.

At Alector, our vision is bold, people are our priority, and our values are at the core of everything we do. Our dynamic and flexible environment encourages our teams to experiment, take ownership of decisions, and question convention to solve complex problems. We value shared wins, perseverance, and a growth mindset, which drives us forward, together.  

Among the things you'll discover at Alector from your very first day are our committed and driven colleagues, a bold company vision, and new, modern offices designed to inspire innovation and collaboration in South San Francisco, right at the heart of Biotech Bay. Our benefits are thoughtfully designed around Alectorians and their loved ones and include flexible hybrid work options, competitive compensation, and comprehensive and unique benefits that enhance your health and well-being. Come join us! 

We believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.  

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation. 

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