Process Development Senior Engineering Scientific Associate (Contract)

Job Description

Vertex has established a new research site in Boston Seaport where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat—and even cure—several of the

Diseases Vertex is focused on include sickle cell disease and type 1 diabetes. Further investment in a research site to advance these programs will be essential to Vertex’s continued and sustained leadership in these exciting approaches. At Vertex Cell and

Genetic Therapies (VCGT): our teams will bring together the best biology, technologies, and

enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to

patients as quickly as possible.

General Summary:

Vertex seeks a highly skilled individual to join our Process Development team as a temporary worker. In this pivotal role, you will spearhead the late-phase process development/engineering activities for drug substance processes for one of our crucial cell and gene therapy assets. As a research associate, you will play a significant part in our internal process development work, optimizing cell-based bioreactor processes to enhance robustness, decrease aseptic risk, increase yields, and reduce the cost of goods. Your contributions may extend to process characterization and technology transfer of manufacturing processes. Based in our Boston, MA, facilities, this position offers a unique opportunity to substantially impact Vertex's mission to bring innovative therapies to patients.

The Process Development group offers a dynamic and challenging environment, perfect for individuals who thrive in fast-paced, high-energy settings. The ideal candidate will be a subject matter expert in process engineering or relevant fields with a solid technical operations background.

The Process Dev Engineering Scientific Associate will be part of a team responsible for process development and optimization and the optimization and characterization of cell-based products and combination products. This lab-based role focuses on formulation development and aseptic fill-finish operations for cell therapy programs.

Project Description: Pluripotent stem cell culture and differentiation support process development. The researcher conducts experiments, documents results, and contributes to team discussions. The researcher utilizes cell biology techniques and statistical principles to support process improvement. The researcher works with bioreactors, spinners, and T-flasks to pass and expand stem cells.

Key Responsibilities:

• Execute experiments to develop robust manufacturing processes for cell therapy products and implement them to support clinical development programs. Manage and execute pluripotent stem cell culture and differentiation to support process development, optimization, and characterization.
• Manage troubleshooting with a high degree of complexity.
• Document experimental procedures and results according to established guidelines. Perform statistical analysis of experimental data to determine critical process parameter ranges.
• Collaborate effectively within departmental teams and contribute to deliverables in a cross-functional environment,
• Ability to run and design an experiment related to cell therapy with the goal of process improvement: cell passaging and expansion in 2D(adhesion) and 3D(suspension).
• Coordinate resources and set priorities for own team, contributing to the department's overall goals.

Requirements:

• BS in Biochemistry, Engineering, Biology, or related discipline with 5+ years of industry experience; an MS with 1+ years of industry experience;
• Able to independently execute, analyze, and document cell culture processes for biologics and cell therapy products.
• Experience working with cell processing devices and bioreactors.
• Working knowledge of GMP requirements.
• Excellent verbal and written communication skills and ability to handle multiple tasks while meeting timelines and adapting to changing priorities.
• Strong organizational skills and high attention to detail.

Contract duration: 12 month with a chance to extend

 Weekend work to support cell culture activities will be required.

Pay Range

$38/hr. - $42/hr.

Shift/Hours

Monday - Friday.

WEEKEND WORK WILL BE REQUIRED

Requisition Disclaimer

This job posting is for a temporary role with a third-party agency partner on assignment at Vertex Pharmaceuticals (“Vertex”). The individual selected for this role will be offered the role as an employee of a third- party agency partner; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors, including skills, competencies, experience, location and/or being pursued and other job-related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirements

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