Senior Engineer, Bioengineering Instrumentation Systems

Spear Bio, founded in 2021, is a well-funded and rapidly growing biotech start-up headquartered in Woburn, Massachusetts.  Our proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), is a novel wash-free immunoassay platform, offering unprecedented sensitivity. We are dedicated to revolutionizing early disease diagnosis and monitoring by providing scalable, ultrasensitive solutions that deliver unparalleled accuracy in measuring low-abundant biomarkers, enabling clinicians and researchers to improve patient outcomes and advance global health.

We are seeking a Senior Systems Integration Engineer to contribute to workflow automation and instrumentation integration activities that connect our assays with advanced hardware and software platforms. This role requires a systems-oriented thinker who can work across biology, mechatronics, and software to design, integrate, and refine complex systems. You will collaborate closely with internal teams and external CDMO partners to drive systematic integration, testing, and deployment of end-to-end solutions.

Key Responsibilities:

Workflow Automation & Instrumentation

• Design, implement, and optimize automated workflow protocols using FAST platforms and other advanced liquid handling systems.

• Develop software tools for instrument control, workflow automation, and integration with data pipelines.

  Systems Design & Integration

• Define integration schemas for module-to-module system-level integration.

• Break down systems into submodules for testing, troubleshooting, and staged integration.

• Drive system-level validation and performance benchmarking in collaboration with CDMO partners.

  Software & Data Tools

• Build versatile tools for workflow scheduling, data acquisition, and pipeline integration.

• Support system data analysis and instrument performance monitoring.

  Cross-Disciplinary Collaboration

• Partner with assay development scientists to translate proteomics and molecular biology protocols into robust automated workflows.

• Work with hardware and software engineers to align mechatronic subsystems and automation platforms with assay requirements.

Qualifications:

Education & Experience

• Master’s or Ph.D. in Mechanical/Electrical Engineering, Biomedical Engineering, Bioengineering, or related field.

• 5+ years of experience in systems integration, instrumentation design, or automation engineering specifically in biotech/diagnostics industry required

  Technical Skills

• Strong foundation in systems engineering and integration methodologies.

• Hands-on experience with liquid handling systems and other workflow automation platforms (prior FAST and qPCR module integration experience).

• Familiarity with mechatronics, robotics, and thermal/optics subsystems.

• Proficiency in software development for instrument control and automation (Python, C#, or similar).

• Familiarity with data analysis and workflow/pipeline integration tools.

Domain Knowledge:

• Exposure to proteomics, molecular biology assays, or related life science applications.

• Experience integrating assay workflows with hardware and software platforms.

Soft Skills:

• Strong problem-solving and troubleshooting skills.

• Excellent communication and collaboration abilities across disciplines.

• Ability to work systematically in fast-paced, collaborative environments.

We offer competitive compensation, meaningful stock ownership, comprehensive benefits, and a great work environment. This is an opportunity to enter an innovative, high-growth startup at an early stage and play an integral role in the company's growth and success. We are focused on identifying candidates who have demonstrated leadership and excellence throughout their careers and are excited by the prospect of building an industry-leading company.

Spear Bio Inc. provides equal opportunity in employment to all persons. No person shall be denied equal access because of race, creed, color, religion, national origin, sex, sexual orientation, gender identity, age, or physical/mental disability.

Spear Bio does not accept resume submissions from external recruiting agencies. Any unsolicited resumes or candidate information submitted without prior written agreement will be deemed the property of Spear Bio, and no placement fees will be paid.