Associate/Sr. Associate Scientist - mRNA Production
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
Position Summary:
The Lilly Gene Therapy group is seeking an independent, self-motivated, and highly skilled scientist who will help build the company’s mRNA production and mRNA technology exploration platform. The successful candidate will support R&D efforts within the company, focused on pre-clinical mRNA production and exploration of therapeutic mRNA optimization strategies. A deep technical background in mRNA biochemistry, mRNA synthesis, and mRNA purification is required. Strong organizational and communication skills, creative problem-solving, and flexibility is essential.
Job Responsibilities:
- Produce mRNA samples to support internal and external collaborations.
- Perform routine biochemistry experiments, including in vitro transcription, purification, quality evaluation, etc.
- Collaborate with CMC and production teams to harmonize pre-clinical and clinical grade production technology and quality metrics.
- Develop and utilize strategies to synthesize and modify RNA molecules to achieve desired properties.
- Contribute to projects directly at the bench.
- Clearly communicate results and recommendations to collaborators, colleagues, managers, and senior management.
Basic Qualifications:
- Masters Degree in Molecular Biology, Biochemistry, Biotechnology or related scientific field with 2+ years of relevant post-graduate work experience. Or a Bachelors Degree in those areas with 5+ years of relevant post-graduate work experience.
Additional Skills/Preferences:
- Hands-on experience with mRNA synthesis and purification techniques is required.
- Hands-on experience with ÄKTA systems and UNICORN control software is required.
- Track record of conducting laboratory experiments, excellent documentation review and writing skills, and the flexibility to work on multiple projects as needed.
- In-depth understanding of purification of biologics, specifically mRNA, including process scale-up. A proven track record of purifying multiple drug modalities is strongly preferred.
- Experience and understanding of technical challenges with mRNA as a therapeutic modality is required. Experience with several mRNA modalities (linear mRNA, saRNA, circRNA, etc.) is an advantage.
- Track record of completing deliverables within specified timelines.
- Strong organizational, communication, and interpersonal skills are required, as well as the ability to work both independently and in a collaborative work environment.
- Familiarity with Design-of-Experiments (DOE) is a plus.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$69,000 - $179,300Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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