Research Scientist, Computational Science

JOB SUMMARY

We are seeking a skilled and highly motivated Research Scientist to join our Computational Sciences group at the Iambic Therapeutics headquarters in San Diego. You will be a key player in the application of advanced ML techniques to drive our drug discovery efforts. You will play an active role in the research teams pursuing important therapeutics across multiple indications. You will work in a cross-functional team, collaborating closely with computational chemists, medicinal chemists and biologists to apply ML models across hit identification, lead optimization, and candidate selection phases. This is a hands-on application scientist role, requiring technical expertise in ML, familiarity with the drug discovery process and a drug-hunter mindset.

KEY RESPONSIBILITIES

• Design, train, evaluate and deploy ML models for predicting drug-target interactions and molecular properties

• Apply ML models to the prioritization of virtual molecules: including de novo design ideas, HTE libraries and commercial collections

• Partner with computational chemists, medicinal chemists and biologists to leverage ML insights for decision-making

• Serve as a bridge between the bench and our computational platforms

• Translate scientific questions into computational workflows and deliver actionable results

• Present results to project teams and senior leadership, explaining methods, implications and recommendations

• Collaborate with ML group to optimize model performance and evolve platforms

REQUIRED QUALIFICATIONS

• PhD or equivalent degree in a computational field, or commensurate job experience

• Skills: Python programming, statistics, drug discovery

• Able to locate in San Diego

PREFERRED QUALIFICATIONS

• PhD or equivalent degree in computational chemistry or machine learning

• 2+ years of experience working in a drug discovery project

• Experience with molecular modeling/structure-based drug design and cheminformatics

ABOUT IAMBIC THERAPEUTICS

Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.

MISSION & CORE VALUES

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

PAY AND BENEFITS

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.