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Pioneering Medicines: Executive Director (MD), Therapeutic Innovation image - Rise Careers
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Pioneering Medicines: Executive Director (MD), Therapeutic Innovation

Pioneering Medicines, an initiative of Flagship Pioneering, builds world-class biopharmaceutical R&D capabilities to discover and develop transformative therapies across multiple modalities and therapeutic areas. We are seeking an Executive Director, Product (Therapeutic) Concept Innovation to define and execute long-term strategy, lead a team of up to eight, and translate platform-derived science into prioritized, translatable therapeutic opportunities aligned with enterprise goals.

Skills

  • MD or MD/PhD with deep translational science expertise
  • Proven track record advancing concepts to clinical candidate nomination or early IND-stage
  • Strategic prioritization and portfolio management
  • Cross-functional leadership and stakeholder influence
  • Strong understanding of drug development and regulatory landscape
  • Operational planning, resourcing, and milestone-driven execution
  • External partnership and collaboration experience

Responsibilities

  • Define and drive a cohesive product concept innovation strategy translating platform science into therapeutic opportunities.
  • Lead cross-functional assessment, prioritization, and shaping of product concepts from ideation through early validation.
  • Serve as senior thought partner to platform leaders, therapeutic experts, and stakeholders to integrate scientific, clinical, and strategic perspectives.
  • Build frameworks for early decision-making, portfolio entry, milestone progression, and resource allocation.
  • Guide concept development to ensure scientific rigor, translational potential, and readiness for development-stage transition.
  • Establish consistent approaches for concept evaluation, milestone tracking, scenario planning, and operational transparency.
  • Represent PCI in leadership forums, governance bodies, and external partnerships to influence enterprise-level decisions.

Education

  • MD or MD/PhD in life sciences, medicine, or related fields
  • Clinical or translational research training
  • Relevant leadership or executive development preferred

Benefits

  • Opportunity to lead high-impact therapeutic innovation with patient-facing impact
  • Competitive compensation and equity participation
  • Comprehensive health and retirement benefits
  • Professional development and leadership growth opportunities
  • Collaborative, inclusive culture focused on bold science and innovation
  • Paid time off and standard employee benefits
To read the complete job description, please click on the ‘Apply’ button

Average salary estimate

$325000 / YEARLY (est.)
min
max
$225000K
$425000K

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Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied... a unique, hypothesis-driven innovation proces...

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SENIORITY LEVEL REQUIREMENT
TEAM SIZE
SALARY RANGE
$225,000/yr - $425,000/yr
EMPLOYMENT TYPE
Full-time, onsite
DATE POSTED
August 13, 2025
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