Director, Toxicology

At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world.  Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases.  

Why Choose Editas?

At Editas Medicine, we’re a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what’s possible in medicine, come join us and become an Editor!

Decoding The Role:

Editas Medicine is seeking a highly accomplished and experienced toxicologist, and a seasoned leader to join our DMPK, Nonclinical Safety and Translational Sciences (DSTS) team. In this leadership role, you will serve as the Head of Toxicology within Editas and be responsible for overseeing all nonclinical safety assessment related activities in rodent and non-rodent models. The successful candidate will apply their knowledge, expertise and drug development experience to advance our gene editing pipeline. The responsibilities include developing and implementing comprehensive strategies to fully integrate with the programs team objectives at all stages of development. The ideal candidate will have strong technical skills, a broad understanding of drug discovery and development, strong foundational knowledge and ability to work collaboratively with key partners in a matrix team structure. The individual in this role should be an independent thinker, collaborative, possess team-player mindset, and ability to thrive in a fast-paced environment. Prior experience with lipid nanoparticle based (LNP) delivery systems and/or gene editing products is a plus. The individual in this critical role will be an integral part of the nonclinical leadership team and will have the opportunity to help build the department to meet the business needs and to bring life changing therapies to patients with genetic disorders.

Characterizing Your Impact:

As the Director, Toxicology you will:

• Develop phase-appropriate nonclinical safety strategies and execution to support Editas’ pipeline.
• Lead the design and oversee execution of GLP and non-GLP toxicology studies to support regulatory submissions and interactions with health authorities, including the authoring of nonclinical safety sections of US and international regulatory applications
• Manage CRO relationships and collaborate with the internal team to drive CRO selection, study monitoring and reporting to ensure scientific rigor, meeting timelines, budgets, and regulatory compliance
• Deliver high-quality safety reports to support clinical plans and regulatory filing submissions in multiple markets
• Serve as the toxicology and/or nonclinical representative (provide subject matter expertise) in cross-functional meetings both internally and externally

The Ideal Transcript:

To thrive in this role, you’ll need:

• PhD in toxicology, pharmacology or related field (preference for DABT certified) with 10+ years of industry experience
• Core expertise in toxicology with emphasis on general toxicology, genotoxicity, developmental and reproductive toxicology
• Track record of advancing programs through nonclinical development including managing GLP and non-GLP studies, and regulatory submissions
• Familiarity with FDA/EMA/ICH guidelines and proven track record of successful health authority interactions
• Experience with gene editing or gene delivery technologies and lipid nanoparticle delivery is highly desired
• Preference will be given to candidates who demonstrate deep interest in translational toxicology
• Outstanding communication skills, both written and oral, and an ability to constantly adapt in a fast-paced dynamic biotech environment
• Desirable personal attributes include strong organization skills, positive attitude, highly collaborative mindset and attention to detail.

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

Salary Range:

$220,000 - $240,000

Pay Transparency

Editas Medicine is committed to transparency and accuracy in our hiring practices. The anticipated salary range for each position is posted within the role. The final salary offer will be determined based on a comprehensive assessment of the candidate's qualifications, including education, training, and relevant experience. Additional factors such as external market conditions, the role's criticality, and internal equity will also be considered. Editas Medicine's compensation philosophy ensures fair and equitable pay practices.

Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases.