Senior Scientist I, Machine Learning in Migraine and Neuroscience

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

AbbVie Neuroscience is expanding its Discovery (The Advanced Cell Technologies, Screening and Sequencing) team in Cambridge, Massachusetts, which will work closely with the Migraine team as well as other Neuroscience pillars. This position in ACTS is focused on combining computational and experimental approaches to identify and validate new targets for the treatment of neurological diseases.

We are seeking a highly motivated scientist largely focused on using datasets derived from disease tissue to address these needs. The successful candidate will play a crucial role in developing and implementing cutting-edge computational approaches to improve our understanding of migraine and neurologic disease pathophysiology, the biology underlying drug non-response, and identify novel targets. Specifically, this role will involve integrating multi-omics data, building gene regulatory network models, and leveraging machine learning techniques. 

The person will work in a multi-disciplinary, cross-functional team analyzing multi-omics datasets to derive insights into migraine and other neurological diseases, and identify novel therapeutic targets specific to patient cohorts. In addition, the candidate will contribute to presentations at scientific conferences, publications of translational findings in peer reviewed journals, new drug applications, and regulatory filings. If you are passionate about translating complex biological data into actionable insights and contributing to the development of medicines for debilitating diseases, we encourage you to apply.

Key Responsibilities

• Multi-Omics Integration:
  • Integrate diverse omics data (e.g., gene expression, proteomics, genomics) to infer shared regulatory networks of migraine and pain.
  • Collaborate with cross-functional teams to identify potential drug targets and optimize therapeutic strategies.
• Machine Learning Model Use and/or Development:
  • Utilize and/or develop machine learning methods to assess target prioritization.
  • Utilize internal omics data to predict drug responses and optimize treatment outcomes, and perform perturbation analysis
• Scientific Communication:
  • Interpret findings and effectively communicate scientific data, concepts, and recommendations to internal stakeholders.
  • Participate in feature design, code reviews, and technical discussions.
• Single Cell Analysis Strategies:
  • Establish and develop novel analysis strategies for single-cell RNA-seq, and other OMICS data.
  • Leverage single-cell data to identify context-specific regulatory networks associated with disease targets and biomarkers.
• External Collaborations:
  • Provide expertise and technical consultation for external collaborations and partnerships with academia and industry.
  • Contribute to collaborative projects that address critical gaps in drug response prediction.

Basic Qualifications:

• Bachelor’s Degree or equivalent education and typically, 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary.
• PhD or MS degree in bioinformatics, statistics, mathematics, computer science, computational biology, genomics, molecular biology, neuroscience, or a related field.
• 5+ years of experience in relevant research or industry roles is required for applicants with master's degree.
• Proficiency in statistical and programming languages (e.g., R, Python).
• Hands-on experience with multi-omics data integration strategies, and/or electronic health records data.
• Experience with cloud computing environments.
• Experience in functional interpretation of -omics data (e.g., RNA-seq, proteomics, genomics) and pathway enrichment.
• Strong knowledge of machine learning techniques (classification, clustering, auto-encoders, reinforcement learning, transfer learning).
• Exposure to in vitro laboratory techniques.

Preferred Qualifications:

• Publications and Contributions: A track record of publications or contributions in relevant scientific journals or conferences.
• Neuroscience Knowledge: Understanding of molecular and cell biology, neuroscience, and migraine biology.
• Proficiency in in vitro laboratory techniques, such as cell culture, molecular biology techniques, assay development.
• Collaborative and Dynamic Work Style: Ability to thrive in a multiple-tasked, fast-paced, highly collaborative, and dynamic work environment.
• Effective Communication Skills: A proactive scientist with outstanding presentation and communication skills that foster collaboration and teamwork.

 Key AbbVie Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.

• Learns fast, grasps the “essence” and can change course quickly where indicated.

• Raises the bar and is never satisfied with the status quo.

• Creates a learning environment, open to suggestions and experimentation for improvement.

• Embraces the ideas of others and nurtures innovation to make possibilities real.
• An individual with a strong work ethic, ability to work in a dynamic environment and able to manage multiple objectives in parallel and adapt to changing priorities.

Applicable only to applicants applying to a position in any location with pay disclosure requirements understate or local law: ​​

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• The compensation range described below is the range of possible base pay compensation that theCompany believes in good faith it will pay for this role at the time of this posting based on the job gradefor this position. Individual compensation paid within this range will depend on many factors includinggeographic location, and we may ultimately pay more or less than the posted range. This range may bemodified in the future.​​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/vision insurance and 401(k) to eligible employees.​​

• This job is eligible to participate in our short-term incentive programs. ​​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested,and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any otherform of compensation and benefits that are allocable to a particular employee remains in the Company'ssole and absolute discretion unless and until paid and may be modified at the Company’s sole andabsolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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