Scientist II or Senior Scientist I, Immune Cell Depletion

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

We are seeking a highly motivated and innovative scientist to join our Immune Cell Depletion Group within the Immunology Discovery Research Immune Tolerance team in Cambridge, MA. The successful candidate will play a key role in supporting in vitro immunology research across multiple stages of drug discovery—from early target validation to late-stage candidate optimization.

This individual will contribute to studies aimed at understanding the biology of pathogenic immune cell populations in autoimmune diseases such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA). The ideal candidate will be detail-oriented, independent, and collaborative, with extensive experience in primary human immune cell assays, multi-color flow cytometry, and general immunological techniques as well as in-depth knowledge of cellular depletion modalities.

You will work closely with cross-functional teams to explore therapeutic hypotheses, design and execute experiments, analyze data, innovate and implement new experimental protocols and present findings that directly inform portfolio decision-making.

Key Responsibilities

• Independently design and execute experiments and interpret data to validate biological hypotheses and support target identification, validation, and mechanistic studies within the Immune Cell Depletion Group.
• Isolate and characterize immune cell subsets from human and mouse blood and tissues for downstream analyses.
• Develop and perform functional assays using cell lines and primary immune cells, including activation, differentiation, immune profiling, and antibody-mediated depletion (ADCC, ADCP, CDC).
• Apply molecular and cellular biology techniques (e.g., multi-color flow cytometry, qPCR, ELISA, MSD, Western blot) to generate high-quality, reproducible data.
• Clearly communicate results through internal presentations, team meetings, and written reports.
• Troubleshoot experimental challenges and apply innovative solutions to advance program objectives.
• Collaborate effectively across multidisciplinary teams and contribute to multiple projects simultaneously under tight timelines.
• Stay current on relevant scientific literature and incorporate new insights into experimental strategies.
• Maintain accurate, timely, and compliant laboratory records and electronic notebooks.
• Maintain high productivity in the lab (on-site ~90%) with dedicated time (~10%) for study design and documentation.
• Contribute to publications and external presentations when appropriate.

Qualifications

• BS, MS, or PhD in Immunology, Cell biology, or in a related discipline with expertise in immunology research, with typically 7-11+ (BS), 5-9+ (MS), or 0-3+ (PhD) years of job-related experience.
• Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions.
• Demonstrated ability to learn, understand and master new experimental techniques.
• Demonstrated expertise in in vitro human cell culture including various types of immune cells, and cell-based assay development.
• Proficient in multi-color flow cytometry, including panel design, data acquisition, and analysis for immune cell profiling.
• Hands-on experience with functional assays such as ADCC, ADCP, and CDC.
• Strong technical skills in immunoassays, including qPCR, ELISA, MSD, and Western blotting.
• Experience in biologic drug screening, fluorescence microscopy, organoid culture, or tissue dissociation/ex vivo processing is highly desirable.
• Familiarity with analyzing or interpreting omics data (e.g., scRNA-seq, spatial transcriptomics) is a plus.
• Ability to adapt quickly, troubleshoot effectively, and manage multiple priorities in a fast-paced research environment is a must.
• Excellent communication and interpersonal skills, with the ability to work both independently and within cross-functional teams.
• Highly organized and committed to scientific rigor and data integrity.
• Proactive and collaborative mindset, with the flexibility to support evolving project needs.

Position will be filled at level commensurate with extent of education, experience, and accomplishment - Scientist II or Senior Scientist I

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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