Associate Director, Obesity Metabolism and Muscle Disease

Regeneron seeks a leader in skeletal muscle physiology and biology to head its research and therapeutic development team.  This group uses various cutting-edge molecular cell biology, genetic, and transcriptomic profiling techniques, as well as genetic animal models to understand muscle physiology and pathophysiology at the cellular and molecular level. This group is committed to understanding the fundamental molecular mechanisms of muscle development and function aiming to identify new therapeutic and diagnostic platforms for a range of muscle degenerative diseases and inflammatory conditions.

This leadership role requires a deep expertise in skeletal muscle biology, preferably with a strong track record in translational research and therapeutic development. The successful candidate will possess excellent communication skills and the ability to inspire multidisciplinary teams to achieve ambitious scientific goals. Specifically they provide strategic guidance, driving technological advancement, and critically assessing data and projects across the preclinical scientific team. The position encompasses progression of drug targets from discovery through clinical development, and representation of Regeneron’s muscle therapeutics strategy to both Senior Leadership and externally.

A Typical Day May Include:

• Establish the strategic framework for muscle biology research, including identification of new therapeutic targets—particularly for genetic diseases—and incorporation of emerging technologies and scientific developments into the research pipeline.
• Design, coordinate, and supervise complex in vitro (cell culture) and in vivo (innovative animal model) studies investigating muscle development, physiological and metabolic function, regeneration, and disease mechanisms.
• Guide, and manage a team of talented scientists, research associates, and technical professionals to deliver high-caliber, rigorous, and impactful research results.
• Lead and set clear short- and long-term objectives to ensure the production of quality scientific output.
• Oversee project workflows, making critical decisions regarding project continuation, and facilitating the efficient transition of drug targets through developmental stages.
• Actively engage in cross-functional, and leadership meetings, contributing expertise in muscle cell biology and advocating the team’s vision.
• Promote collaboration between therapeutic areas and technology groups, fostering relationships and utilizing resources to enhance research outcomes.
• Review and authorize muscle-related documentation, including regulatory submissions, manuscripts, and contracts.

This role might be for you if you have:

• Experience with cutting-edge technologies and their application to muscular disorders such as genetic targeting with siRNA, shRNA, CRISPR/Cas9, AAVs is advantageous
• Exceptional written and verbal communication skills, with the ability to articulate scientific concepts and strategic vision.
• Proven leadership, managerial, and mentorship abilities and the ability to work in a matrix environment.
• Experience in group administration, including budget and organizational management.
• Exposure to drug development or regulated activities is highly desirable.
• Strong professional network, publication record, and national/international reputation preferred.

To be considered for this position, we are looking for:

• PhD in Molecular Biology, Biomedicine, Biochemistry, Human Biology, Human Skeletal or Exercise Physiology, or a related discipline. 
• Extensive cellular and molecular biology expertise in muscle biology and metabolism is desirable.
• Minimum of 5-10 years post-PhD experience and at least 2-5 years in industry or translational settings preferred.