Scientist I – Human iPSC-derived Neuron Culture and Assay Development

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

We are seeking a highly motivated scientist to join our team and advance the development of iPSC-derived neuron cultures for psychiatry drug discovery. In this role, you will work with human iPSCs, differentiating them into various neuronal types and performing assays to assess neuronal function and monitor disease-relevant phenotypes. You will have the opportunity to explore the mechanisms of therapeutic molecules and present your findings at internal meetings. The successful candidate is a dynamic team player with strong communication skills, eager to learn, and committed to improving the quality of life for patients with psychiatric disorders. Key responsibilities include iPSC culture and differentiation, as well as general lab management. This is an exciting opportunity for a passionate scientist who wishes to develop their career within the industry and make a tangible impact in discovering new treatments for patients.

Key Responsibilities

• Conduct cell culture and banking of human induced pluripotent stem cells (iPSCs), iPSC-derived neurons, and primary neuronal cultures
• Differentiate human iPSCs into desired neuronal cell types
• Evaluate compound efficacy using biochemical and molecular biology techniques, such as immunostaining, qPCR, western blot, and enzymatic assays
• Perform in vitro electrophysiology experiments to assess neuronal activity
• Work independently in the lab, analyze results, and present findings to the team for feedback.
• Collaborate and communicate effectively with internal colleagues across the organization as well as external partners on occasion
• Demonstrate strong data analysis and interpretation skills
• Assist in developing cell-based assays, including high content imaging and quantitative microscopy assays.
• Independently generate accurate, reliable and reproducible data in a timely manner and keep detailed experimental records
• Mentoring of junior Associates, Co-op students and interns

Required Qualifications

• Bachelor’s Degree or equivalent education with typically 5 years of experience, or Master’s Degree or equivalent education with typically two years of experience.
• Hands-on experience with neuronal culture
• Strong organizational skills and attention to detail in handling all tasks.
• Ability to manage multiple projects amid shifting priorities and thrive in a fast-paced research environment.
• Proficiency in sterile techniques and basic cellular and molecular biology lab skills.
• Enthusiasm for conducting lab-based research to drive discovery efforts in neuropsychiatric disorders.
• Familiarity with reading, interpreting, and adapting methods from primary literature
• Collaborative, proactive, and curious nature.
• Strong communication and collaboration skills for effective work within a multidisciplinary team.
• A passion for learning new methods and techniques, with a strong desire to be an independent scientist.
• Attention to detail, and record keeping using an electronic lab notebook.

Qualifications

• Previous experience with iPSC culture
• Proficiency in the principles of neurobiology and cell biology
• Prior experience in drug discovery, particularly in psychiatry
• Experience with high content imaging assays

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​​

• This job is eligible to participate in our short-term incentive programs. ​​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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