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Sr. Principal Engineer-Data

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Eli Lilly and Company seeks a Sr. Principal Engineer-Data to engage in technical leadership within Lilly Research Labs. Ensure technical designs align with architecture guidance and adhering to data platform standards and ensure data quality, consistency, and security across the organization. Design and implement scalable data architectures to support complex tech and business needs and requirements. Guide the team in the impact analysis to translate and implement technical design (configuration/development and data integration). Enhance the performance and efficiency of data pipelines, identifying bottlenecks and implementing solutions for seamless data and information flow. Manage sophisticated data engineering projects effectively, ensuring timely delivery and alignment to industry-specific regulations. Exhibit strong communication and problem-solving skills to collaborate with a variety of partners. Understand emerging technology trends and disruptions and the practical application of existing, new, and emerging technologies to enable new and evolving business and operating models. Grow and maintain knowledge of advanced technology and analytics trends within the organization and across the industry externally.

What You Should Bring

  • AWS Solution Architect Certification
  • Azure Fabric experience
  • Pharmaceutical or healthcare industry experience highly valued
  • Experience developing architecture blueprints and roadmaps
  • Experience collaborating with business team members and portfolio architects to translate future-state business capabilities and requirements into solution architecture requirements

Basic Requirements

  • Bachelor’s degree in Information Management, Computer Science, or a related field
  • 5 + years of progressively responsible experience with software development life cycle, spanning the lifecycle from project initiation to deployment, support, and retirement.
  • Experience architecting, designing, providing solution for data intensive applications in a hybrid cloud environment, leveraging and not limited to, the following technologies
    • AWS Cloud Services under Compute, Storage, Database, Database Migration, Orchestration, Analytics, Infrastructure, etc.
    • Big Data Technologies such as spark, pyspark for near-real time data processing
    • Expertise in one or more programming languages like Python, NodeJS, etc.
    • Required experience with Microservice system design, cloud performance design, cloud hosting and DevOps
    • Expertise with data ingestion, data products, consumption enablement, analytics and AI/ML solutions.
    • Knowledge of code versioning tools such as Github
    • Experience developing architecture blueprints and roadmaps

Organization Overview

Lilly IT builds and maintains capabilities using cutting edge technologies like most prominent tech companies. What differentiates Lilly IT is that we redefine what’s possible through tech to advance our purpose – creating medicines that make life better for people around the world, like data driven drug discovery and connected clinical trials. We hire the best technology professionals from a variety of backgrounds, so they can bring an assortment of knowledge, skills, and diverse thinking to deliver innovative solutions in every area of our business.

Research Tech unites science with technology to accelerate the Research and Development of medicines and to deliver therapeutic innovations. The team leverages technology and platforms to streamline scientific experimentation to help Researchers follow the science, to understand the disease and identify potential therapies. They are at the forefront of advanced analytics to enable data driven drug discovery, to innovate so Scientists can rapidly analyze and accelerate the discovery of new medicines.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.


Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$63,750 - $180,400

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

Average salary estimate

$122075 / YEARLY (est.)
min
max
$63750K
$180400K

If an employer mentions a salary or salary range on their job, we display it as an "Employer Estimate". If a job has no salary data, Rise displays an estimate if available.

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Full-time, onsite
DATE POSTED
September 7, 2025
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