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Sr. Technical Project Manager - Product Life Cycle Management

What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Illumina is seeking a Senior Technical Project Manager to drive project execution across a portfolio of projects within Instrument Operations. The candidate must be able to work independently, handle multiple projects in parallel, and communicate effectively across all levels of the organization.

Responsibilities:

  • Own and drive technical projects with SMEs & cross functional groups across sites.

  • Facilitate & Execute Technical Design reviews and Engineering changes with emphasis on best engineering practices.

  • Develop project plans, schedules, resourcing, budget, project risks, and mitigation plans.

  • Track and trend LCM project completions

  • Develop project effectiveness check plans and monitor in conjunction with leadership.

  • Present regular project plan and status updates to senior management to ensure expectations are met and aligned. 

  • Lead strategic project and product development and proposals for new and sustaining projects from Life cycle management perspective (project concept to EOL)

  • Drive continuous improvement initiatives to advance quality processes and capabilities.

Listed responsibilities are an essential, but not exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs.

Requirements:

  • Strong Technical background in project management, operations leadership, continuous improvement and strategic planning.

  • Ability to triangulate information from diverse sources and assimilate into actionable recommendations

  • Demonstrated skills in leading projects involving cross functional teams.

  • 5 years in managing project/programs in the Operations

  • Working knowledge of R&D, GMP Manufacturing, and Software Development from direct or project related experiences

  • Demonstrated strong analytical problem solving (CAPA, Lean, Six Sigma, etc.)

  • Ability to negotiate and influence cross-functionally.

  • Experience in developing, managing, and implementing project metrics.

  • Adaptable to fast-paced, dynamic work environment and constant shifting demands.

  • Working knowledge of leading technical engineering projects (Engineering releases, change management, Product Development Process, Design reviews, Process controls) using standard methodologies (Six Sigma, Kanban, Hybrid, SCRUM, etc.)

  • Work independently, handle multiple projects in parallel, and communicate effectively with all levels of the organization

  • Ability to solve complex problems informed by robust analysis and multiple data points

All listed requirements are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional task and responsibilities.

Education/Experience:

  • Bachelor's degree is required and 5+ years experience in project management.

  • Advanced use of project management tools such as Microsoft Project, Confluence, Jira, etc.

  • Experience working in a regulated environment and familiar with Design Controls for the development of medical devices such as 21CFR820, ISO 13485, and ISO 14971

  • PMP certification is a HUGE plus

The estimated base salary range for the Sr. Technical Project Manager - Product Life Cycle Management role based in the United States of America is: $124,300 - $186,500. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.


We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact [email protected]. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.
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CEO of Illumina
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$155400 / YEARLY (est.)
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$124300K
$186500K

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To improve human health by unlocking the power of the genome.

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Full-time, onsite
DATE POSTED
January 6, 2026
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