Senior Scientist, In Vivo Discovery

About Mote Therapeutics

Are you a scientific leader with a passion for advancing RNA therapeutics and the drive to make a difference in the world? Do you want to be a part of a dynamic and innovative team at the forefront of RNA medicines? If so, join our new RNA Venture and be a part of the revolution in RNA therapeutics!

Backed by Fapon Biotech, an international leader in in vitro diagnostics, biologics, and precision medicines, Mote Therapeutics is an innovative Lexington-based biotechnology startup building the RNA medicines of tomorrow. Led by a pioneer in the field of RNA therapeutics and supported by Fapon’s Greater Boston R&D Center of Excellence, we’re pulling together a team of talented scientists, leaders, and operations specialists to solve some of the major barriers to success that RNA therapeutics face.

About Fapon Biotech

Founded in 2001 and headquartered in Guangdong, China, Fapon Group is mainly engaged in product R&D and services of in vitro diagnostics (IVD), biological therapies, and precision diagnostics and treatments. With our core value of "foresee and prepare for what the future demands", Fapon has historically focused on three major businesses: raw material solutions, IVD ecosystem platform service, and intelligent digital diagnosis and treatment. Fapon’s recent expansion into therapeutics was recently marked by success with the receipt of IND approval from the FDA for a differentiated CD47 antibody drug, the first in a rapidly expanding therapeutics effort.

With a global footprint, Fapon has established major production and sales (R&D) bases in Beijing, Shenzhen, Shanghai, the United States, Germany, India and other locations throughout the world, forming a global R&D, production, marketing, and service network with products being widely sold in 61 countries and regions.

You can learn more about us by visiting https://en.faponbiotech.com

An equal-opportunity employer, Fapon welcomes and encourages diversity in our workforce.

We are seeking a scientific contributor to lead and execute in vivo studies using novel LNP formulations designed to cross the BBB and target cells within the brain. This role will spearhead our CNS program and would be responsible for designing and executing in vivo studies using rodent models as well as downstream bioanalytic methods. The candidate would have the opportunity to work in a collaboration-oriented role in which they would coordinate with other teams, plan and run animal studies with a cross-functional group of scientists, and support the growth and career development of junior scientists. The ideal candidate is a life sciences major with strong in-vivo and ex-vivo analytic techniques who is excited by the idea of being a core participant in building an early startup and guiding the scientific vision of the company. They would be engaged in science and driven by our mission to create therapies that help people in ways that are currently impossible.

Key Responsibilities

• Design, plan and execute in vivo experiments to support LNP based targeted delivery across the blood brain barrier through systemic administration
• Develop bioanalytical assays (cell-based, flow cytometry, ELISA, biomedical imaging) to assess the delivery efficiency of RNA cargo in rodent tissue to facilitate development of neuroscience focused therapeutics pipeline
• Conduct studies in small animals models for brain characterization, biodistribution (qualitative/quantitative), disease model development, efficacy and toxicity assessment
• Contribute to patent applications related to the neuroscience program
• Perform CRO outreach including experimental planning, work coordination and data interpretation for neuroscience program
• Support technology transfer to Industry Partners
• Foster collaborative relationships across the team and company and engage in a positive and exciting work environment
• Contribute to hiring, training, and collaborating with scientists (as needed) to support assessment of efficacy in relevant in vivo models
• Plan and coordinate animal studies with formulations team members
• Author technical documents, including SOPs for analytical methods, maintain diligent records and demonstrate proficiency in scientific communication
• Support high-quality documentations to support regulatory filings

Minimum Qualifications:

• PhD/MS in life sciences, pharmaceutical sciences, or related field, preferably with 1-3/6+ years of relevant experience. The title will be commensurate with experience.
• Experience working with murine animals, including animal handling, dosing (IV, IP, PO, SC), blood collection (submandibular and cardiac) and tissue necropsy
• Prior experience in neuroscience focused research is a must
• Knowledge in brain physiology and cell biology
• Experience in biomolecular analytics (ELISA, PCR, Flow Cytometry)
• Must be eligible to work in the United States

Preferred Qualifications:

• Experience in brain tissue dissection, histology and imaging is a plus
• Strong communication skills and ability to present complex technical topics to diverse audiences with varying technical depth.
• Strong collaborative instinct with good time and resource management skills to match the fast-paced start-up work culture.
• Able to collaborate on and execute multiple parallel studies

What We Offer:

At our RNA Venture, we aim to outmatch the typical benefits you might see in an early startup. We offer:

• Financial security through competitive compensation, incentives, and retirement plan
• Health care and well-being programs including competitive medical, dental, vision & medical benefits
• Generous paid time off including vacation, sick time, holidays, and winter shutdown
• 401(k) retirement savings with a generous company match
• Commuter benefits
• Other comprehensive voluntary benefits include but are not limited to pet insurance, life insurance, employee assistance program (EAP), discount programs, and many more
• We continue to optimize our benefits & wellness programs as we grow our organization to make sure they meet our diverse workforce needs
• The stability of a startup backed by a company with a record of strong financial performance year over year