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Lead Omics Workflow Engineer

Axle is a bioscience and information technology company partnering with top research organizations to modernize translational research and biomedical informatics. We are seeking a Lead Omics Workflow Engineer to own and modernize a library of Nextflow-based omics pipelines, build a comprehensive automated validation framework, and ensure reproducible scientific results across diverse infrastructures.

Skills

  • Expert-level Nextflow workflow development and orchestration
  • Deep domain knowledge of omics pipelines (RNA-seq, WGS, proteomics)
  • Strong software testing and validation practices applied to bioinformatics
  • Linux/Unix proficiency and experience with HPC schedulers (SLURM)
  • Containerization with Docker and Singularity
  • Experience designing modular, stateless pipeline code and CI/CD for workflows
  • Ability to lead technical teams and communicate complex scientific/computational issues

Responsibilities

  • Perform structured review and characterization of ~20+ Nextflow-based omics pipelines, documenting dependencies, execution patterns, and failure modes
  • Architect and implement a unified test suite with representative datasets and regression checks to detect unintended scientific changes
  • Propose and execute tooling, dependency, and container image upgrades while maintaining scientific and security standards
  • Design and operate automated validation workflows to run test suites on demand or in response to code changes
  • Analyze validation results to verify scientific consistency and provide expert interpretation of differences
  • Ensure pipelines are hermetic and portable across on-premise SLURM HPC and Google Cloud Platform

Education

  • Bachelor's degree in Computer Science, Bioinformatics, Computational Biology, or related field, or equivalent experience
  • Advanced degree (MS/PhD) in a relevant field preferred but not required

Benefits

  • 100% medical, dental & vision coverage for employees
  • Paid time off and paid holidays
  • 401(k) match up to 5%
  • Educational benefits for career growth
  • Employee referral bonus
  • Flexible Spending Accounts (Healthcare FSA)
  • Parking reimbursement account (PRK)
  • Dependent care assistance program (DCAP)
  • Transportation reimbursement account (TRN)
To read the complete job description, please click on the ‘Apply’ button
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Average salary estimate

$137500 / YEARLY (est.)
min
max
$125000K
$150000K

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We see Axle as a constant work-in-progress, and the same is true of our people; for all of us, we believe the best is yet to come. Our core values are tenacity, curiosity, empathy and transparency, which we pursue through thoughtful discussion and...

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BENEFITS & PERKS
Dental Insurance
Flexible Spending Account (FSA)
Vision Insurance
FUNDING
SENIORITY LEVEL REQUIREMENT
TEAM SIZE
SALARY RANGE
$125,000/yr - $150,000/yr
EMPLOYMENT TYPE
Full-time, remote
DATE POSTED
January 6, 2026
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